Ferritina como predictor de morbimortalidad en pacientes hipertensos hospitalizados con COVID severo comparada con valores de Dímero D: Una revisión sistemática

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dc.contributor.advisorGiraldo Ospina, Beatriz
dc.contributor.advisorLópez Muñóz, Diego Fernando
dc.contributor.authorCastaño Ospina, Juan Camilo
dc.contributor.orcidhttps://orcid.org/0000-0001-8015-3223spa
dc.contributor.orcidhttps://orcid.org/0009-0001-3130-2613
dc.contributor.orcidhttps://orcid.org/0000-0001-6156-1619
dc.coverage.cityTuluáspa
dc.coverage.spatialTulua, Valle del Cauca, Colombiaspa
dc.date.accessioned2024-06-26T13:43:21Z
dc.date.available2024-06-26T13:43:21Z
dc.date.issued2024
dc.descriptionilustraciones, gráficos, tablasspa
dc.description.abstractIntroducción: La infección por COVID-19 presentó una severidad variable, siendo especialmente grave en pacientes hipertensos debido a los mecanismos asociados al receptor ACE2. La ferritina y el dímero D, biomarcadores inflamatorios, se relacionaron con la gravedad de la enfermedad y variaron significativamente en pacientes hipertensos con COVID-19 severo. El objetivo de este estudio fue evaluar la ferritina como predictor de morbimortalidad en pacientes hipertensos con COVID-19 severo, comparándola con el dímero D. Método: Se realizó una revisión sistemática siguiendo los lineamientos de la estrategia PRISMA (2020). La búsqueda de literatura se llevó a cabo en las bases de datos PubMed (MedLine), Scopus, Science Direct y Web of Science, incluyendo estudios observacionales de población adulta hipertensa hospitalizada por COVID-19 severo que evaluaron la ferritina y el dímero D como predictores de morbimortalidad entre 2019 y 2023. Los hallazgos se describieron cualitativamente, utilizando la lista de verificación PRISMA (2020) y apoyándose en la plataforma Rayyan AI para la selección de estudios. Resultados: Se obtuvo información detallada sobre la utilidad de la ferritina como predictor de morbimortalidad en comparación con el dímero D. Los datos de los estudios seleccionados incluyeron edad, niveles de ferritina y dímero D. La búsqueda inicial arrojó 4586 resultados, de los cuales se seleccionaron 27 estudios para análisis cuantitativo. El análisis reveló que los pacientes adultos hipertensos hospitalizados por COVID-19 severo presentaron incrementos significativos en los niveles de ferritina y dímero D, indicando su relevancia como biomarcadores. Conclusiones: Esta revisión sistemática proporcionó información crucial sobre el valor pronóstico de la ferritina en pacientes hipertensos con COVID-19 severo. Los resultados sugieren que la ferritina podría ser un biomarcador útil para mejorar el manejo clínico de estos pacientes, complementando la información proporcionada por el dímero D. Palabras clave: COVID-19, ferritina, Productos de Degradación de Fibrina-Fibrinógeno, pronóstico, revisión sistemática. (DeCS)spa
dc.description.abstractenglishIntroduction: COVID-19 infection exhibited variable severity, being particularly severe in hypertensive patients due to mechanisms associated with the ACE2 receptor. Ferritin and D- dimer, inflammatory biomarkers, were related to disease severity and varied significantly in hypertensive patients with severe COVID-19. This study aimed to evaluate ferritin as a predictor of morbidity and mortality in hypertensive patients with severe COVID-19, comparing it with D-dimer. Method: A systematic review was conducted following the PRISMA (2020) guidelines. The literature search was performed in the databases PubMed (MedLine), Scopus, Science Direct, and Web of Science, including observational studies of adult hypertensive populations hospitalized with severe COVID-19 that evaluated ferritin and D-dimer as predictors of morbidity and mortality between 2019 and 2023. The findings were described qualitatively, using the PRISMA (2020) checklist and supported by the Rayyan AI platform for study selection. Results: Detailed information was obtained on the utility of ferritin as a predictor of morbidity and mortality compared to D-dimer. Data from the selected studies included age, ferritin levels, and D-dimer levels. The initial search yielded 4586 results, from which 27 studies were selected for quantitative analysis. The analysis revealed that adult hypertensive patients hospitalized with severe COVID-19 showed significant increases in ferritin and D- dimer levels, indicating their relevance as biomarkers. Conclusions: This systematic review provided crucial information on the prognostic value of ferritin in hypertensive patients with severe COVID-19. The results suggest that ferritin could be a useful biomarker for improving the clinical management of these patients, complementing the information provided by D-dimer. Keywords: COVID-19, ferritin, Fibrinogen-Fibrin Degradation Products, prognosis, systematic review. (DeCS)eng
dc.description.degreelevelPregradospa
dc.description.degreenameMedicospa
dc.description.tableofcontentsResumen / Abstract / 1. Planteamiento del problema / 1.1 Justificación / 2. Objetivos / 3. Marco teórico / 4. Métodos / 4.1 Bases de datos y criterios de búsqueda / 4.2 Proceso de selección de estudios / 4.3 Evaluación de la calidad y riesgo de sesgo / 4.4 Extracción y análisis de datos / 4.5 Síntesis y comparación de resultados / 5. Resultados / 5.1 Análisis de datos / 5.2 Resultados clave / 5.3 Implicaciones clínicas / 6. Discusión / 6.1 Hipertensión arterial y mortalidad por COVID-19 / 6.2 Ferritina como predictor de mortalidad / 6.3 Dímero D como Predictor de Mortalidad / 6.4 Comparación entre Ferritina y Dímero D / 6.5 Limitaciones de la revisión / 6.6 Implicaciones clínicas y futuras investigaciones / 7. Conclusiones / 7.1 Recomendaciones para futuros estudiosspa
dc.formatPDFspa
dc.format.extent25 páginasspa
dc.format.mimetypeapplication/pdfspa
dc.identifier.instnameInstname:Unidad Central del Valle del Caucaspa
dc.identifier.reponamereponame:Repositorio Institucional Unidad Central del Valle del Caucaspa
dc.identifier.repourlrepourl:https://repositorio.uceva.edu.co/
dc.identifier.urihttp://hdl.handle.net/20.500.12993/4471
dc.language.isospaspa
dc.publisher.facultyFacultad de Ciencias de la Saludspa
dc.publisher.programMedicinaspa
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dc.rightsDerechos reservados - Unidad Central del Valle del Caucaspa
dc.rights.accessrightsinfo:eu-repo/semantics/openAccessspa
dc.rights.coarhttp://purl.org/coar/access_right/c_abf2spa
dc.rights.licenseAtribución-NoComercial-SinDerivadas 4.0 Internacional (CC BY-NC-ND 4.0)*
dc.rights.localAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0*
dc.subject.keywordsCOVID-19eng
dc.subject.keywordsFerritineng
dc.subject.keywordsFibrinogen-fibrin degradation productseng
dc.subject.keywordsPrognosiseng
dc.subject.keywordsSystematic review (DeCS)eng
dc.subject.proposalCOVID-19spa
dc.subject.proposalFerritinaspa
dc.subject.proposalProductos de degradación de fibrina-fibrinógenospa
dc.subject.proposalPronósticospa
dc.subject.proposalRevisión sistemática (DeCS)spa
dc.titleFerritina como predictor de morbimortalidad en pacientes hipertensos hospitalizados con COVID severo comparada con valores de Dímero D: Una revisión sistemáticaspa
dc.title.titleenglishFerritin as a predictor of morbidity and mortality in hospitalized hypertensive patients with severe COVID compared to D-dimer levels: A systematic reviewspa
dc.typebachelor thesisspa
dc.type.coarhttp://purl.org/coar/resource_type/c_7a1fspa
dc.type.coarversionhttp://purl.org/coar/version/c_ab4af688f83e57aaspa
dc.type.contentTextspa
dc.type.driverinfo:eu-repo/semantics/bachelorThesisspa
dc.type.localTesis/Trabajo de grado - Monografía - Pregradospa
dc.type.versioninfo:eu-repo/semantics/acceptedVersionspa
dcterms.audiencePúblico generalspa
dcterms.audience.professionaldevelopmentPregradospa
dcterms.audience.professionaldevelopmentEspecializaciónspa
dcterms.audience.redcolCiencias de la Saludspa
dcterms.audience.redcolMedicina Clinicaspa

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Autorizacion-jcastano.pdf
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Cesion derechos patrimoniales
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